Cancer Genome and Tumor Microenvironment (Cancer Genetics)
Kindle Edition or EPUB + Converted PDF نویسندگان: Andrei Thomas-Tikhonenko
جزئیات
فرمت: Kindle Edition or EPUB + Converted PDF ناشر: Springer تاریخ انتشار نسخه الکترونیکی : January 23, 2010
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شابک: 9781441907110 لینک: https://www.amazon.com/dp/B008BC0OSW
349,000 تومان
زمان تحویل: حداکثر 24 ساعت
توضیحات
Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ’80s-early ’90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are “soft-wired”, i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.
349,000 تومان
زمان تحویل: حداکثر 24 ساعت