Bridging the Divide: Translating Biology into Therapeutic Advances in Acute Myeloid leukemia (AML)
Kindle Edition or EPUB + Converted PDF نویسندگان: Boyd Mudenda
جزئیات
فرمت: Kindle Edition or EPUB + Converted PDF تاریخ انتشار نسخه الکترونیکی : May 4, 2026
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لینک: https://www.amazon.com/dp/B0GX2WZHQY
5,928,000 تومان
زمان تحویل: حداکثر 24 ساعت
توضیحات
Why has acute myeloid leukemia (AML)—one of the most biologically characterized cancers—remained so difficult to treat?Despite decades of advances in genomics, epigenetics, and clonal evolution, AML continues to resist meaningful therapeutic progress. Clinical responses are often short-lived, relapse is the norm rather than the exception, and curative outcomes still depend largely on transplantation rather than truly disease-specific strategies.In this incisive and authoritative book, a physician and senior clinical development leader with more than 30 years of oncology drug development experience confronts AML’s central paradox: the persistent disconnect between biological insight and clinical success.Going beyond conventional reviews, this work examines:Why promising therapies fail in late-stage trialsHow surrogate endpoints and single-arm studies can misdirect development decisionsThe unique constraints AML imposes on innovation, including toxicity limits and compressed treatment timelinesThe biological determinants of response and toxicityWhy AML biology must directly inform study design and clinical endpointsThis is not simply a catalogue of mutations or therapies. It is a strategic, translational roadmap—integrating disease biology with the realities of drug development, clinical trial design, biomarker strategy, and regulatory decision-making.Written for clinicians, scientists, translational researchers, biotech leaders, and regulators, the book delivers a clear and urgent message:If AML is to achieve the transformative breakthroughs seen in other hematologic malignancies, biology must be aligned with strategy—and development must be designed for success from the outset.
5,928,000 تومان
زمان تحویل: حداکثر 24 ساعت