Autonomic dysfunction is increasingly recognized as a core mechanism underlying a wide spectrum of clinical disorders, yet it remains one of the least systematically understood areas in medicine. This volume provides a structured, clinically grounded framework for understanding how the autonomic nervous system maintains physiologic stability—and how that stability fails.Volume I focuses on the foundational science of autonomic regulation, integrating neuroanatomy, cardiovascular physiology, neuroimmune signaling, and peripheral autonomic function into a unified clinical model. It explains how the body maintains blood pressure, heart rate, vascular tone, thermoregulation, and visceral control through tightly coordinated autonomic networks.Key areas covered include the organization of the autonomic nervous system, baroreflex physiology, cerebral autoregulation, orthostatic hemodynamics, and the role of small fiber and peripheral autonomic pathways in systemic disease. The book also examines neuroimmune and neurovascular interactions, highlighting how inflammation, endothelial dysfunction, and metabolic stress contribute to autonomic instability.Mechanisms of dysfunction are presented in a clinically relevant way, including sympathetic–parasympathetic imbalance, hyperadrenergic states, vasomotor failure, and neurogenic circulatory instability. These principles are directly applied to the understanding of orthostatic intolerance, syncope, multisystem autonomic failure, and early autonomic disease patterns.Rather than treating dysautonomia as a single disorder, this volume frames it as a systems-level failure of physiologic regulation, providing clinicians with a structured way to interpret complex, multisystem presentations.Designed for neurologists, cardiologists, internists, and clinicians in autonomic medicine, this book bridges core physiology with real-world clinical application. It also serves as a reference for researchers and trainees seeking a rigorous, modern understanding of autonomic control systems.Volume I lays the scientific foundation required to interpret, diagnose, and contextualize autonomic disorders in clinical practice.
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