Oncologic Critical Care Diagnosis and Management Handbook: A Clinical Textbook Covering Immunotherapy Toxicities, Tumor Emergencies & ICU Organ Support for Intensivists
Oncologic Critical Care Diagnosis and Management Handbook: A Clinical Textbook Covering Immunotherapy Toxicities, Tumor Emergencies & ICU Organ Support for Intensivists
Kindle Edition or EPUB + Converted PDF
نویسندگان: Conrad S. Collado MD
جزئیات
فرمت: Kindle Edition or EPUB + Converted PDFتاریخ انتشار نسخه الکترونیکی : July 27, 2026
Recognize the Pattern, Act on the Decision — Before the Next Organ FailsThe critically ill cancer patient sits at the intersection of acute physiology and tumor biology, and the intensivist who treats one without understanding the other makes errors in both directions. This reference connects the mechanisms that drive oncologic emergencies — cytokine-mediated shock, neutrophil-absent infection, tumor-driven metabolic crisis, treatment-induced organ injury — to the ICU decisions they demand. It moves from the pathophysiology of CRS and immune checkpoint toxicity through febrile neutropenia, tumor lysis, spinal cord compression, and coagulopathy, and into the palliative care and ethics frameworks that govern when to escalate and when to redirect. Forty-eight named clinical patterns — each carrying a stem signature, decision anchor, and trap logic — turn recognition into bedside infrastructure you can act on under pressure.What This Book Puts in Your Hands• Manage cytokine release syndrome and ICANS after CAR-T therapy — tocilizumab timing at grade 2, ICE score grading, and the cerebral edema progression warning that separates floor monitoring from ICU emergency.• Recognize the silent presentations of neutropenic sepsis — the absent infiltrate, the blunted inflammatory response, and the antifungal escalation cascade triggered at day 4 of persistent fever.• Navigate the DIC-versus-TMA diagnostic fork — fibrinogen as the decision point, ADAMTS13 as the confirmation, and the treatment divergence that makes the wrong call lethal.• Treat ICI myocarditis and the overlap syndrome triad — troponin-triggered immunosuppression, concurrent myositis and myasthenia screening, and the mortality rate that early recognition cuts in half.• Prevent the calcium-phosphate precipitation trap in tumor lysis — product monitoring, rasburicase dosing, and the CRRT threshold that precedes calcium correction.• Apply time-limited trials and structured goals-of-care frameworks — defined milestones, reassessment dates, and the communication architecture that aligns ICU intensity with patient values.Order your copy and bring the pattern library to the bedside where your next oncology patient is waiting.
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