صفحه‌اصلی
دسته بندی ها
دیابت
Diabetes and Obesity: Pathophysiology, Clinical Evidence, and Emerging Therapeutics

Diabetes and Obesity: Pathophysiology, Clinical Evidence, and Emerging Therapeutics

Kindle Edition or EPUB + Converted PDF نویسندگان: Wren Hollowbrook

جزئیات

فرمت: Kindle Edition or EPUB + Converted PDF تاریخ انتشار نسخه الکترونیکی : July 30, 2026 لینک: https://www.amazon.com/dp/B0HC5SWH4B

توضیحات

See diabetes and obesity as two distinct, deeply interconnected diseases.Why do some people with obesity never develop diabetes, while others develop dysglycemia at a lower body weight? Why can the same A1c or BMI signal very different risks? What connects insulin resistance, beta-cell failure, appetite biology, ectopic fat, cardiovascular disease, chronic kidney disease, fatty liver disease, and weight recurrence—and where do those pathways diverge?Diabetes and Obesity: Pathophysiology, Clinical Evidence, and Emerging Therapeutics is a comprehensive graduate-level textbook that connects molecular mechanisms to clinical decisions across the full spectrum of metabolic and cardiometabolic disease.Across ten parts and seventy chapters, Wren Hollowbrook builds an integrated framework for understanding normal fuel metabolism, disease development, diagnosis, risk stratification, treatment, prevention, and care across the life course. Complex science is organized around the questions that matter in practice: what is happening biologically, what the evidence can actually prove, which outcomes matter to patients, and how treatment choices change with comorbidities, safety, access, and individual goals.Inside this book, readers will explore:Glucose homeostasis, lipid metabolism, energy balance, endocrine control, insulin signaling, adipose-tissue biology, inflammation, the microbiome, and neuroendocrine regulation of appetite and body weightType 1 diabetes, type 2 diabetes, prediabetes, gestational diabetes, monogenic and secondary diabetes, diabetic emergencies, and microvascular complicationsObesity phenotypes, limitations of BMI, body composition, adaptive thermogenesis, weight recurrence, weight stigma, and ethical, person-centered careCardiometabolic complications including atherosclerotic cardiovascular disease, heart failure, chronic kidney disease, MASLD and MASH, hypertension, dyslipidemia, PCOS, and sleep apneaClinical assessment, laboratory interpretation, cardiovascular risk, continuous glucose monitoring, glycemic variability, imaging, precision medicine, genomics, and digital health dataNutrition therapy, physical activity, behavioral care, insulin, GLP-1 and other incretin-based therapies, SGLT2 inhibitors, anti-obesity pharmacotherapy, metabolic surgery, and diabetes technologyEmerging approaches including multiagonist and amylin combinations, glucose-responsive insulin, immune therapy, beta-cell replacement, fibrosis-directed liver treatment, and artificial intelligencePrevention, implementation science, food systems, affordability, health equity, population health, pregnancy, childhood, aging, acute care, and transitions between settingsThis is not a collection of isolated facts or a one-cause theory of metabolic disease. It distinguishes mechanism from association, surrogate markers from patient-important outcomes, and promising innovation from established benefit. Landmark trials and guidelines are used as tools for reasoning, with attention to applicability, uncertainty, adverse effects, treatment burden, durability, cost, and access.Learning objectives, clinical pearls, mechanism-focused explanations, misconception checks, research frontiers, integrated diagrams, summary points, and review questions make the text useful for structured study and rapid reference.Designed for medical and graduate students, residents, fellows, physicians, nurses, pharmacists, dietitians, diabetes educators, researchers, public health professionals, and advanced readers, this book offers the depth of a specialist reference with a coherent systems-based structure.Understand the mechanisms. Appraise the evidence. Connect modern treatment to the outcomes that matter most.

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